Our Research

Research and Stuides from Neurobehavioral Research Inc.NRI specializes in using EEG, structural MRI and neuropsychological and behavior assessment to study the effects of drugs and diseases on brain structure and function.
Current Studies

Brain Morbidity in Treatment-Naive Alcoholics

Most studies on the impact of alcohol dependence on the brain have examined individuals in treatment, or shortly thereafter. Such samples represent only about a quarter of alcohol dependent individuals in the general population.

In the previous five years of work, we studied 21-50 year old actively drinking treatment-naive alcohol dependent individuals and age and gender comparable controls, and compared them to our other ongoing study of 35-55 year old long-term abstinent treated alcohol dependent individuals and their age and gender comparable controls. We showed that with regard to alcohol intake in the initial period after starting abusive drinking, treatment-naive alcohol dependent individuals were a subpopulation with lower initial heavy alcohol consumption than abstinent treated and not simply observed earlier in the progression of the disease. The current study will continue to examine the same issues in an older sample of 35-60 year old treatment-naive alcohol dependent individuals, half with and half without concomitant drug abuse/dependence.

Long-term Abstinent Alcoholics: Clinical Issues and Central Nervous System (CNS) Disinhibition

Extends our work in studying long-term abstinent alcoholics with comparison samples of short-term abstinent alcoholics, and both short- and long-term abstinent alcoholics with concomitant drug and alcohol dependence.

Our preliminary/prior data showed clearly that LTAAs were very deviant prone, poorly socialized, made decisions that were strongly governed by immediate rewards, and evidenced reduced amygdala volumes, all characteristics associated with antisocial behavior, yet engaged minimally in such behavior. A focus of the work proposed here is to determine whether the neurobiological disinhibitory underpinnings of externalizing illness have changed with abstinence, or whether the predisposition is unchanged, but kept under wraps by higher cognitive functions. In addition, this would allow us to replicate, with greater sensitivity, our prior work in long-term abstinence, recruiting both short- and long-term alcoholics with comorbid drug dependence, so that the generalizability of our potential findings to the U.S. population would be (greatly) improved. Moreover, we believe that the findings from alcohol-dependent individuals with versus without comorbid drug dependence will differ with regard to the function of disinhibitory brain systems, comorbid psychiatric disturbance, and cognitive recovery. Our purpose is not to look at specific drug effects, but to test the hypothesis that individuals with comorbid drug dependence are sicker; i.e., having greater disability and lesser recovery than individuals with alcohol dependence alone.



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2012

Gait and Balance in Treatment-Naive Active Alcoholics with and without a Lifetime Drug Codependence

Fein, G., Smith, S., Greenstein, D., Alcohol Clin Exp Res, In Press
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2011

Borderline Personality Symptoms in Short-Term and Long Term Abstinent Alcohol Dependence

Fein, G., Nip, V., Alcohol Clin Exp Res, In Press
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Age effect on subcortical structure in healthy adults

Goodro, M., Sameti, M., Patenaude, B, Fein, G., Psychiatry Research: Neuroimaging, In Press
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Growth and weight status in treatment-naive 12-16 year old adolescents with alcohol use disorders in Cape Town, South Africa

Naude, C., Senekal, M., Laubscher, R., Carey P., Fein, G., Nutrition Journal
PubMed Central

Methamphetamine users show greater than normal age-related cortical grey matter loss

Nakama, H., Chang, L., Fein, G., Shimotsu, R., Jiang, C., Ernst, T., Addiction, In Press
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Persistent but less severe ataxia in long-term vs. short-term abstinent alcoholic men and women: A cross sectional analysis

Smith, S.,Fein, G., Alcohol Clin Exp Res, In Press
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Lymphocyte measures in treatment-naive 13-15 year old adolescents with alcohol use disorders

Naude, C., Bouic, P., Senekal, M., Kidd, M., Ferrett, H., Fein, G., Carey, P., Alcohol, 2011 Aug:45(5):507-514
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Characterization of South African adolescents with alcohol use disorders but without psychiatric or polysubstance comorbidity

Ferrett, H., Cuzen, N., Thomas, K., Carey, P., Stein, D., Finn, P., Fein, G., Alcohol Clin Exp Res, In Press
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Event-related potentials during visual target detection in treatment-naive active alcoholics

Fein, G., Andrew, C., Alcohol Clin Exp Res, 2011, Jun;35(6):1171-1179.
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Subcortical volumes in long-term abstinent alcoholics: Associations with psychiatric comorbidity

Sameti, M., Smith, S., Patenaude, B., Fein, G., Alcohol Clin Exp Res, In Press
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2010

Cognitive performance in treatment-naive active alcoholics

Smith, S., Fein, G., Alcohol Clin Exp Res, 2010 Dec;34(12):2097-2105
PubMed Central

Neuropsychological performance of South African treatment-naive adolescents with alcohol dependence

Ferrett H. L., Carey, P. D., Thomas, K. G., Tapert, S. F.,Fein, G., Drug and Alcohol Depend, 2010 July 1;110(1-2):8-14
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Sensation seeking in long-term abstinent alcoholics, treatment-naive alcoholics and non-alcoholic controls

Fein, G., Di Sclafani, V., Finn, P, Alcohol Clin Exp Res, 2010 June;34(6):1045-1051
Pubmed Central

ERP and RT delays in long-term abstinent alcoholics in processing of emotional facial expressions during gender and emotion categorization tasks

Fein, G., Key, K., Szymanski, M, Alcohol Clin Exp Res, 2010 July;34(7):1127-1139
PubMed Central

Induced theta oscillations as biomarkers for alcoholism

Andrew, C. and G. Fein J Clin Neurophysiol, 2010 Mar;121(3):350-58
PubMed Central

Event-related oscillations versus event-related potentials in a P300 task as biomarkers for alcoholism

Andrew, C. and G. Fein, Alcohol Clin Exp Res, 2010 Apr 1;34(4):669-80
PubMed Central

Age-related gray matter shrinkage in a treatment naive actively drinking alcohol dependent sample

Fein, G., Shimotsu, R., and J. Barakos, Alcohol Clin Exp Res, 2010 Jan;34(1):175-82
PubMed Central

2009

Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men

Fein, G., Shimotsu, R., Chu R., and J. Barakos, Alcohol Clin Exp Res, 2009 Oct;33(10):1806-14
PubMed Central

Early adolescent development is impacted by heavy alcohol use: Preliminary evidence of grey matter changes using VBM

Fouche, J.P., Carey, P.D., Spottiswoode, B., Ferrett, H., Patenaude, B., Tapert, S., and G. Fein, Research Society of Alcoholism Conference 2009, San Diego, CA
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Psychiatric co-morbidity in Native Hawaiian and Pacific Islanders compared to other populations: Measurement and clinical issues

Fein, G. and V. Di Sclafani, Hawaii Addictions Conference/ AAPI Workgroup Scientific Conference, May 12, 2009, Honolulu, HI
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Greater than age-related decline in temporal and occipital cortices of methamphetamine users

Nakama, H., Shimotsu, R., Ernst, T., Fein, G., and L. Chang, International Society for Magnetic Resonance in Medicine 2009 Conference. April 22, 2009, Honolulu, HI
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Localized cortical gray matter loss in long-term abstinent alcoholics

Shimotsu, R. and G. Fein, International Society for Magnetic Resonance in Medicine 2009 Conference. April 22, 2009, Honolulu, HI
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Increased white matter signal hyperintensities in long-term abstinent alcoholics compared to non-alcoholic controls

Fein, G., Shimotsu, R., Di Sclafani, V., Barakos, J., and C. Harper, Alcohol Clin Exp Res, 2009, 33(1), 70-8
PubMed Central


2008

Psychiatric comorbidity in older long-term abstinent alcoholics

Fein, G., Di Sclafani, V., Finn, P., and R. Shumway, Addictive Behaviors, 2008, 33(12), 1564-71
PubMed Central

Treatment-naive active alcoholics have greater psychiatric comorbidity than normal controls but less than treated abstinent alcoholics

Di Sclafani V., Finn, P., and G. Fein, Drug and Alcohol Depend, 2008, 98(1-2), 115-22
PubMed Central

Smaller feedback ERN amplitudes during the BART are associated with a greater family history density of alcohol problems in treatment-naive alcoholics

Fein, G., and M. Chang, Drug Alcohol Depend, 2008, 92(1-3), 141-148
PubMed Central


2007

Cognitive performance in long-term abstinent elderly alcoholics

Fein, G., and S. McGillivray, Alcohol Clin Exp Res, 2007, 31(11), 1788-1799
PubMed Central

Psychiatric comorbidity in long-term abstinent alcoholics

Di Sclafani, V., Finn, P., and G. Fein, Alcohol Clin Exp Res, 2007, 31(5), 793-803
PubMed Central

Older adults make less advantageous decisions than younger adults: cognitive and psychological correlates

Fein, G., McGillivray, S., and P. Finn, J Int Neuropsychol Soc, 2007, 13(3), 480-489
PubMed Central

Sub-diagnostic psychiatric comorbidity in alcoholics

Fein, G., Di Sclafani, V., Finn, P., and D.L. Scheiner, Drug Alcohol Depend, 2007. 87(2-3): p.139-145
PubMed Central Journal Website


2006

Visual P300s in long-term abstinent chronic alcoholics

Fein, G., and M. Chang, Alcohol Clin Exp Res, 2006. 30(12): p. 2000-2007
PubMed Central

Cognitive performance in long-term abstinent alcoholic individuals

Fein, G., Torres, J., Price, L.J., and V. Di Sclafani, Alcohol Clin Exp Res, 2006. 30(9): p.1-7
PubMed Central

Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task

Fein, G., Landman, B., Tran, H., McGillvray, S., Finn, P., Barakos, J., and K. Moon, NeuroImage, 2006. 32(3): p.1465-71
PubMed Central

Statistical parametric mapping of brain morphology: sensitivity is dramatically increased by using brain-extracted images as inputs

Fein, G., Landman, B., Tran, H., Barakos, J., Moon, K., Di Sclafani, V., and R. Shumway, NeuroImage, 2006. 30(4): p.1187-1195
PubMed Central

Normal performance on a simulated gambling task in treatment-naive alcohol-dependent individuals

Fein, G., McGillivray, S., and P. Finn, Alcohol Clin Exp Res, 2006. 30(6): p.959-66
PubMed Central


2005

EEG spectral changes in treatment-naive, actively drinking alcoholics

Fein, G. and J. Allen, Alcohol Clin Exp Res, 2005. 29(4): p. 538-46
PubMed Central

Treated and treatment-naive alcoholics come from different populations

Fein, G. and B. Landman, Alcohol, 2005. 35(1): p. 19-26
PubMed Central

The pathophysiology of 'brain shrinkage' in alcoholics: structural and molecular changes and clinical implications

Harper, C., Matsumoto, I., Pfefferbaum, A., Adalsteinsson, E., Sullivan, E., Lewohl, J., Dodd, P., Taylor, M., Fein, G., and B. Landman, Alcohol Clin Exp Res, 2005. 29(6): p. 1106-1115
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2004

Mismatch negativity: no difference between controls and abstinent alcoholics

Fein, G., Whitlow, B., and P. Finn, Alcohol Clin Exp Res, 2004. 28(1): p. 137-42
PubMed Central

Cerebral reserve capacity: implications for alcohol and drug abuse

Fein, G. and V. Di Sclafani, Alcohol, 2004. 32(1): p. 63-7
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Controlling for premorbid brain size in imaging studies: T1-derived cranium scaling factor vs. T2-derived intracranial vault volume

Fein, G., Di Sclafani, V., Taylor, C.J., Moon, K., Barakos, J., Tran, H., Landman, B. and R. Shumway, Psychiatry Res, 2004. 131(2): p. 169-76
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Impairment on a simulated gambling task in long-term abstinent alcoholics

Fein, G., L. Klein, and P. Finn, Alcohol Clin Exp Res, 2004. 28(10): p. 1487-91
PubMed Central

Mismatch negativity: no difference between treatment-naive alcoholics and controls

Fein, G., S. McGillivray, and P. Finn, Alcohol Clin Exp Res, 2004. 28(12): p. 1861-6
PubMed Central


2002

Neuropsychological performance of individuals dependent on crack-cocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence

Di Sclafani, V., Tolou-Shams, M., Price, L.J., and G. Fein, Drug Alcohol Depend, 2002. 66(2): p. 161-71
PubMed Central

Cortical gray matter loss in treatment-naive alcohol dependent individuals

Fein, G., Di Sclafani, V., Cardenas, V.A., Goldmann, H., Tolou-Shams, M. and D.J. Meyerhoff, Alcohol Clin Exp Res, 2002. 26(4): p. 558-64
PubMed Central

Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men

Fein, G., V. Di Sclafani, and D.J. Meyerhoff, Drug Alcohol Depend, 2002. 68(1): p. 87-93
PubMed Central

Alpha2-noradrenergic effects on ERP and behavioral indices of auditory information processing

Turetsky, B.I. and G. Fein, Psychophysiology, 2002. 39(2): p. 147-57
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2001

Reliability of tissue volumes and their spatial distribution for segmented magnetic resonance images

Cardenas, V.A., Ezekiel, F., Di Sclafani, V., Gomberg, B. and G. Fein, Psychiatry Res, 2001. 106(3): p. 193-205
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Effects of chronic alcohol consumption on the broad phospholipid signal in human brain: an in vivo 31P MRS study

Estilaei, M.R., Matson, G.B., Payne, G.S., Leach, M.O., Fein, G. and D.J. Meyerhoff, Alcohol Clin Exp Res, 2001. 25(1): p. 89-97
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Effects of abstinence from alcohol on the broad phospholipid signal in human brain: an in vivo 31P magnetic resonance spectroscopy study

Estilaei, M.R., Matson, G.B., Payne, G.S., Leach, M.O., Fein, G. and D.J. Meyerhoff, Alcohol Clin Exp Res, 2001. 25(8): p. 1213-20
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2000

Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy

Capizzano, A.A., Schuff, N., Amend, D.L., Tanabe, J.L., Norman, D., Maudsley, A.A., Jagust, W., Chui, H. C., Fein, G., Segal, M.R. and M.W. Weiner, Am J Neuroradiol, 2000. 21(4): p. 621-30
PubMed Central

Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease

Fein, G., Di Sclafani, V., Tanabe, J.L., Cardenas, V.A., Weiner, M.W., Jagust, W.J., Reed, B.R., Norman, D., Schuff, N., Kusdra, L., Greenfield, T. and H. Chui, Neurology, 2000. 55(11): p. 1626-35
PubMed Central

Ethanol in human brain by magnetic resonance spectroscopy: correlation with blood and breath levels, relaxation, and magnetization transfer

Fein, G. and D.J. Meyerhoff, Alcohol Clin Exp Res, 2000. 24(8): p. 1227-35
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1999

Differential association of HIV-related neuropsychological impairment with semantic versus repetition priming

Jasiukaitis, P. and G. Fein, J Int Neuropsychol Soc, 1999. 5(5): p. 434-41
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Intact visual word priming in cocaine dependent subjects with and without cognitive deficit

Jasiukaitis, P. and G. Fein, Prog Neuropsychopharmacol Biol Psychiatry, 1999. 23(6): p. 1019-36
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Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients

Meyerhoff, D.J., Bloomer, C., Cardenas, V., Norman, D., Weiner, M.W. and G. Fein, Neurology, 1999. 52(5): p. 995-1003
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Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging

Meyerhoff, D.J., Bloomer, C.W., Schuff, N., Ezekiel, F., Norman, D., Clark, W., Weiner, M.W. and G. Fein, Addiction Biology, 1999. 4: p. 405-419
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Sensory gating in chronic posttraumatic stress disorder: reduced auditory P50 suppression in combat veterans

Neylan, T.C., Fletcher, D.J., Lenoci, M., McCallin, K., Weiss, D.S., Schoenfeld, F.B., Marmar, C.R. and G. Fein, Biol Psychiatry, 1999. 46(12): p. 1656-64
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Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging

Schuff, N., Amend, D.L., Knowlton, R., Norman, D., Fein, G. and M.W. Weiner, Neurobiol Aging, 1999. 20(3): p. 279-85
PubMed Central

Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia

Tanabe, J.L., Ezekiel, F., Jagust, W.J., Reed, B.R., Norman, D., Schuff, N., Weiner, M.W., Chui, H. and G. Fein, Am J Neuroradiol, 1999. 20(5): p. 839-44
PubMed Central

1998

Very late pain-related activity identified with topographically mapped frequency domain analysis of evoked potentials

Becker, D.E., Noss, R.S., Fein, G. and C.D. Yingling, Electroencephalogr Clin Neurophysiol, 1998. 108(4): p. 398-405
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Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy

Deicken, R.F., Zhou, L., Schuff, N., Fein, G. and M.W. Weiner, Biol Psychiatry, 1998. 43(7): p. 483-8
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Premorbid brain size is a determinant of functional reserve in abstinent crack-cocaine and crack-cocaine-alcohol-dependent adults

Di Sclafani, V., Clark, H.W., Tolou-Shams, M., Bloomer, C.W., Salas, G.A., Norman, D. and G. Fein, J Int Neuropsychol Soc, 1998. 4(6): p. 559-65
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Abstinent chronic crack-cocaine and crack-cocaine/alcohol abusers evidence normal hippocampal volumes on MRI despite persistent cognitive impairments

Di Sclafani, V., Truran, D., Bloomer, C., Tolou-Shams, M., Clark, H.W., Norman, D., Hannauer, D. and G. Fein, Addiction Biology, 1998. 3: p. 261-270
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Effect of chronic alcohol abuse on the CNS morbidity of HIV disease

Fein, G., Fletcher, D.J. and V. Di Sclafani, Alcohol Clin Exp Res, 1998. 22(5 Suppl): p. 196S-200S
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Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain

Schuff, N., Amend, D.L., Meyerhoff, D.J., Tanabe, J.L., Norman, D., Fein, G. and M.W. Weiner, Radiology, 1998. 207(1): p. 91-102
PubMed Central

1997

Event-related potential evidence for frontal cortex effects of chronic cocaine dependence

Biggins, C.A., MacKay, S., Clark, W. and G. Fein Biol Psychiatry, 1997. 42(6): p. 472-85,
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Human P50 suppression is not affected by variations in wakeful alertness

Cardenas, V.A., Gill, P. and G. Fein, Biol Psychiatry, 1997. 41(8): p. 891-901

A comparison of the repetitive click and conditioning-testing P50 paradigms

Cardenas, V.A., McCallin, K., Hopkins, R. and G. Fein, Electroencephalogr Clin Neurophysiol, 1997. 104(2): p. 157-64
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Computerized assessment of arithmetic computation skills with MicroCog

Devivo, K., Rothland, J., Price, L. and G. Fein, J Int Neuropsychol Soc, 1997. 3(2): p. 199-200; author reply 200
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Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment

Di Sclafani, V., Mackay, R.D., Meyerhoff, D.J., Norman, D., Weiner, M.W. and G. Fein, J Int Neuropsychol Soc, 1997. 3(3): p. 276-87
PubMed Central

Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain

Schuff, N., Amend, D.L., Meyerhoff, D.J., Tanabe, J.L., Norman, D., Fein, G. and M.W. Weiner, Radiology, 1998. 207(1): p. 91-102
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Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging

Ende, G.R., Laxer, K.D., Knowlton, R.C., Matson, G.B., Schuff, N., Fein, G. and M.W. Weiner, Radiology, 1997. 202(3): p. 809-17
PubMed Central

Intra-hemispheric alpha coherence decreases with increasing cognitive impairment in HIV patients

Fletcher, D.J., J. Raz, and G. Fein, Electroencephalogr Clin Neurophysiol, 1997. 102(4): p. 286-94
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Presurgical multimodality neuroimaging in electroencephalographic lateralized temporal lobe epilepsy

Knowlton, R.C., Laxer, K.D., Ende, G., Hawkins, R.A., Wong, S.T., Matson, G.B., Rowley, H. A., Fein, G. and M.W. Weiner, Ann Neurol, 1997. 42(6): p. 829-37
PubMed Central

P50 event-related brain potential amplitude and suppression measurements recorded with subjects seated versus supine

McCallin, K., V.A. Cardenas, and G. Fein, Biol Psychiatry, 1997. 41(8): p. 902-5
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Semantic priming impairment in HIV

Nielsen-Bohlman, L., Boyle, D., Biggins, C., Ezekiel, F. and G. Fein, Int Neuropsychol Soc, 1997. 3(4): p. 348-58
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Sensory gating deficit following cocaine exposure in the rat

Salamy, A., M. Salfi, and G. Fein, Neuropsychobiology, 1997. 36(2): p. 83-6
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Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study

Schuff, N., Amend, D., Ezekiel, F., Steinman, S.K., Tanabe, J., Norman, D., Jagust, W., Kramer, J. H., Mastrianni, J. A., Fein, G. and M.W. Weiner, Neurology, 1997. 49(6): p. 1513-21
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Reduced hippocampal volume and n-acetyl aspartate in posttraumatic stress disorder

Schuff, N., Marmar, C.R., Weiss, D.S., Neylan, T.C., Schoenfeld, F., Fein, G. and M.W. Weiner, Ann N Y Acad Sci, 1997. 821: p. 516-20

Tissue segmentation of the brain in Alzheimer disease

Tanabe, J.L., Amend, D., Schuff, N., DiSclafani, V., Ezekiel, F., Norman, D., Fein, G. and M.W. Weiner, AJNR Am J Neuroradiol, 1997. 18(1): p. 115-23

Volumetric method for evaluating magnetization transfer ratio of tissue categories: application to areas of white matter signal hyperintensity in the elderly

Tanabe, J.L., Ezekiel, F., Jagust, W.J., Schuff, N. and G. Fein, Radiology, 1997. 204(2): p. 570-5
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1996

Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics

Fein, G., C. Biggins, and S. MacKay, Biol Psychiatry, 1996. 39(11): p. 955-65
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Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging

MacKay, S., Ezekiel, F., Di Sclafani, V., Meyerhoff, D.J., Gerson, J., Norman, D., Fein, G. and M.W. Weiner, Radiology, 1996. 198(2): p. 537-45
PubMed Central

Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging

MacKay, S., Meyerhoff, D.J., Constans, J.M., Norman, D., Fein, G. and M.W. Weiner, Arch Neurol, 1996. 53(2): p. 167-74
PubMed Central

Deep gray matter structures in HIV infection: a proton MR spectroscopic study

Meyerhoff, D.J., M.W. Weiner, and G. Fein, AJNR Am J Neuroradiol, 1996. 17(5): p. 973-8
PubMed Central

Do semantic priming effects correlate with sensory gating in schizophrenia?

Vinogradov, S., Solomon, S., Ober, B.A., Biggins, C.A., Shenaut, G.K. and G. Fein, Biol Psychiatry, 1996. 39(9): p. 821-4
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1995

Dreaming in the late morning: summation of REM and diurnal cortical activation

Antrobus, J., Kondo, T., Reinsel, R. and G. Fein, Conscious Cogn, 1995. 4(3): p. 275-99
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Delayed P3A in abstinent elderly male chronic alcoholics

Biggins, C.A., MacKay, S., Poole, N. and G. Fein, Alcohol Clin Exp Res, 1995. 19(4): p. 1032-42

A multichannel, model-free method for estimation of event-related potential amplitudes and its comparison with dipole source localization

Cardenas, V.A., Yingling, C.D., Jewett, D. and G. Fein, J Med Eng Technol, 1995. 19(2-3): p. 88-98
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H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia

Constans, J.M., Meyerhoff, D.J., Gerson, J., MacKay, S., Norman, D., Fein, G. and M.W. Weiner, Radiology, 1995. 197(2): p. 517-23
PubMed Central

1H and 31P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects

Constans, J.M., Meyerhoff, D.J., Norman, D., Fein, G. and M.W. Weiner, Neuroradiology, 1995. 37(8): p. 615-23
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Basal ganglia phosphorous metabolism in chronic schizophrenia

Deicken, R.F., Calabrese, G., Merrin, E.L., Fein, G., and M.W. Weiner, Am J Psychiatry, 1995. 152(1): p. 126-9
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Asymmetry of temporal lobe phosphorous metabolism in schizophrenia: a 31phosphorous magnetic resonance spectroscopic imaging study

Deicken, R.F., Calabrese, G., Merrin, E.L., Vinogradov, S., Fein, G. and M.W. Weiner, Biol Psychiatry, 1995. 38(5): p. 279-86
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Abnormal frontal lobe phosphorous metabolism in bipolar disorder

Deicken, R.F., G. Fein, and M.W. Weiner, Am J Psychiatry, 1995. 152(6): p. 915-8
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Decreased temporal lobe phosphomonoesters in bipolar disorder

Deicken, R.F., M.W. Weiner, and G. Fein, J Affect Disord, 1995. 33(3): p. 195-9
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Brain atrophy and cognitive function in older abstinent alcoholic men

Di Sclafani, V., Ezekiel, F., Meyerhoff, D.J., MacKay, S., Dillon, W.P., Weiner, M.W. and G. Fein, Alcohol Clin Exp Res, 1995. 19(5): p. 1121-6
PubMed Central

Alcohol abuse and HIV infection have additive effects on frontal cortex function as measured by auditory evoked potential P3A latency

Fein, G., C.A. Biggins, and S. MacKay, Biol Psychiatry, 1995. 37(3): p. 183-95
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Delayed latency of the event-related brain potential P3A component in HIV disease. Progressive effects with increasing cognitive impairment

Fein, G., C.A. Biggins, and S. MacKay, Arch Neurol, 1995. 52(11): p. 1109-18
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Improved method for computation of potentials in a realistic head shape model

Fletcher, D.J., Amir, A., Jewett, D.L. and G. Fein, IEEE Trans Biomed Eng, 1995. 42(11): p. 1094-104
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Combining MRI segmentation and 1H MR spectroscopic imaging in the study of Alzheimer